Transgenic Neuroscience Research: Exploring the Scientific Opportunities Afforded by New Nonhuman Primate Models: Proceedings of a Workshop


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On October 4, 2018, the Forum on Neuroscience and Nervous System Disorders hosted a 1-day public workshop that brought together experts and key stakeholders from academia, government, industry, and nonprofit organizations to examine the scientific opportunities and challenges, as well as bioethical considerations, of genetically engineered nonhuman primate models for neuroscience research. This Proceedings of a Workshop highlights presentations that discussed the state of the science of transgenic and chimeric neuroscience research, and how emerging models may advance understanding of brain function and therapies for nervous system disorders. The Proceedings also summarizes workshop discussions that examined current tools and technologies used in rodent models and how they may translate to use in nonhuman primate models; considered bioethical principles and issues related to genetic engineering of nonhuman primate models for nervous system disorders; and discussed policies and infrastructure needed to advance research in this domain.